Effects of chronic delta-9-THC treatment on cardiac beta-adrenoceptors in rats

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(87)90209-7· OSTI ID:5607626

Evans, E B; Seifen, E; Kennedy, R H; Kafiluddi, R; Paule, M G; Scallet, A C; Ali, S F; Slikker, W Jr

This study was designed to determine if chronic treatment with delta-9-tetrahydrocannabinol (THC) alters cardiac beta-adrenoceptors in the rat. Following daily oral administration of 10 or 20 mg/kg THC or an equivalent volume of control solvent for 90 days, rats were sacrificed, and sarcolemmal membranes were prepared from ventricular myocardium. Beta-adrenoceptor density and binding affinity estimated with (-)(/sup 3/H)dihydroalprenolol; a beta-adrenergic antagonist, were not significantly affected by treatment with THC when compared to vehicle controls. These results suggest that the tolerance to cardiovascular effects of THC which develops during chronic exposure in the rat is not associated with alterations in cardiac beta-adrenoceptors as monitored by radiolabeled antagonist binding.

• Research Organization: Univ. of Arkansas for Medical Sciences, Little Rock
• OSTI ID: 5607626
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 28:2; ISSN PBBHA
• Country of Publication: United States
• Language: English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HEART
HERBS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MARIHUANA
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PLANTS
PROTEINS
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES