Biological transport of curium-243 in dairy animals. [Comparison to /sup 241/Am kinetics in lactating cows and goats]

Technical Report · Sun Apr 01 04:00:00 EST 1979

DOI:https://doi.org/10.2172/6061017· OSTI ID:6061017

Sutton, W. W.; Patzer, R. G.; Hahn, P. B.; Potter, G. D.

Lactating cows and goats were used to examine the biological transport of curium-243 in dairy animals. After either single oral or intravenous nuclide doses were administered, samples of milk, urine, blood, and feces were taken over a 144-hr priod, and the curium concentrations were determined by gamma counting. Gastrointestinal uptake of curium was estimated to be 0.02 and 0.006% of the oral dose for cows and goats, respectively. The cumulative percentage of oral dose transported to milk and urine was 4.6 x 10/sup -4/ and 1.9 x 10/sup -3/, respectively, for a cow and 2.7 x 10/sup -4/ and 1.6 x 10/sup -4/, respectively, for goats. Plasma concentrations of curium decreased rapidly following all intravenous injections. The average percentage of injected curium transferred to milk, urine, and feces was 2, 8, and 1, respectively, for a cow and 2, 5, and 5, respectively, for goats. All animals were sacrificed one week after dosing. Bovine bone retained the greatest fraction of the administered dose and the next highest was the liver. However, in all three intravenously dosed goats the liver contained the greatest amount of curium. Nuclide deposition in bone and liver was essentially equal for two of the three orally dosed goats while the skeleton contained the most curium in the other animal. Comparisons are presented between curium-243 and americium-241 transport in dairy cows.

• Research Organization: Environmental Protection Agency, Las Vegas, NV (USA). Environmental Monitoring and Support Lab.
• OSTI ID: 6061017
• Report Number(s): EMSL-LV-0539-23
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CATTLE
CLEARANCE
COMPARATIVE EVALUATIONS
COWS
CURIUM 243
CURIUM ISOTOPES
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FECES
FOOD
GLANDS
GOATS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LACTATION
LIVER
MAMMALS
MILK
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORAL ADMINISTRATION
ORGANS
RADIOACTIVITY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUMINANTS
SINGLE INTAKE
SKELETON
TISSUE DISTRIBUTION
UPTAKE
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES