Quantitative in vivo studies of hyperemia in the course of the tissue response to biomaterial implantation
- Unite 37 INSERM, Bron (France)
Hyperemia associated with an inflammatory response has been investigated in rats, by using four different experimental models, i.e., positive and negative polymer implants from the pharmacopea, operative control, and abscess induced by turpentine oil. 133Xenon clearance, infrared thermography and Laser Doppler Flowmetry (LDF) were used to monitor the subcutaneous local hemodynamic changes from 1 to 40 postoperative days. LDF proved to be a sensitive, reproducible method, able to discriminate positive from negative implants already at the 3rd postoperative day and up to 40 days. This increased local blood flow was also visualized at the site of positive implants at the 14th and 21st postoperative days by means of 133Xe Clearance. Additional information obtained by infrared thermography allowed discrimination between positive implants and control sites but only at the very early stage (1 to 3 days). The significance of the different data collected by the three techniques was correlated with histological events occurring at the different implant sites. LDF may therefore represent a useful technique for noninvasive semiquantitative assessment of tissue response to biomaterials.
- OSTI ID:
- 6060444
- Journal Information:
- Journal of Biomedical Materials Research; (USA), Vol. 24:11; ISSN 0021-9304
- Country of Publication:
- United States
- Language:
- English
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BIOLOGICAL MATERIALS
IMPLANTS
GRAFT-HOST REACTION
DIAGNOSIS
BLOOD FLOW
BODY TEMPERATURE
INFLAMMATION
INFRARED THERMOGRAPHY
RATS
SKIN
XENON 133
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEASURING METHODS
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RODENTS
SYMPTOMS
THERMOGRAPHY
VERTEBRATES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics