Metabolism of radioactive and stable strontium in man
Although strontium and calcium are chemically similar and both are bone seekers, the metabolism of these minerals differs greatly in humans. Radioactive strontium is preferentially excreted in urine and the intestinal absorption is considerably lower than of calcium. These two processes lead to decreased retention of radioactive strontium. Since the urinary radiostrontium excretion varies with the urinary calcium excretion, several compounds which increase the urinary calcium excretion were used in order to increase the urinary and radiostrontium excretion. This procedure can be used for decontamination and for decreasing the radiostrontium body burden. Aluminum phosphate gel, an antacid, is highly effective in inhibiting the intestinal absorption or radiostrontium while compounds containing either aluminum only or phosphate alone were also effective but to a considerably lesser extent. 23 references, 2 figures, 4 tables.
- Research Organization:
- Veterans Administration Hospital, Hines, IL
- OSTI ID:
- 6059633
- Report Number(s):
- CONF-860626-
- Journal Information:
- Trace Subst. Environ. Health; (United States), Journal Name: Trace Subst. Environ. Health; (United States); ISSN PUMTA
- Country of Publication:
- United States
- Language:
- English
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Kinetics
& Toxicology-- Man
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ALUMINIUM COMPOUNDS
ALUMINIUM PHOSPHATES
BODY BURDEN
CALCIUM
DATA
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
INHIBITION
INTESTINAL ABSORPTION
ISOTOPES
METABOLISM
METALS
NUMERICAL DATA
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIONUCLIDE KINETICS
RETENTION
STRONTIUM
STRONTIUM ISOTOPES
UPTAKE