Response of human fibroblasts to low dose rate gamma irradiation
Journal Article
·
· Radiat. Res.; (United States)
Cells from 11 human strains, including fibroblasts from patients with the genetic diseases of ataxia telangiectasia (AT), xeroderma pigmentosum (XP), and Fanconi's anemia (FA), were exposed to ..gamma.. radiation at high (1.6-2.2 Gy/min) and at low (0.03-0.07 Gy/min) dose rates. Survival curves reveal an increase inthe terminal slope (D/sub 0/) when cells are irradiated at low dose rates compared to high dose rates. This was true for all cell lines tested, although the AT, FA, and XP cells are reported or postulated to have radiation repair deficiencies. From the response of these cells, it is apparent that radiation sensitivities differ; however, at low dose rate, all tested human cells are able to repair injury.
- Research Organization:
- Georgetown Univ. Medical Center, Washington, DC
- OSTI ID:
- 6054894
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DISEASES
DOSE RATES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FIBROBLASTS
GAMMA RADIATION
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PRIMATES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SURVIVAL CURVES
SYMPTOMS
TELANGIECTASIS
VASCULAR DISEASES
VERTEBRATES
XP CELLS
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DISEASES
DOSE RATES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FIBROBLASTS
GAMMA RADIATION
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PRIMATES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SURVIVAL CURVES
SYMPTOMS
TELANGIECTASIS
VASCULAR DISEASES
VERTEBRATES
XP CELLS
YEARS LIVING RADIOISOTOPES