Adsorption of methylmercury from hair ingested by rats

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(93)90125-M· OSTI ID:6054773

Farris, F F ^[1]; Dedrick, R L ^[2]

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1. Food and Drug Administration, Rockville, MD (United States)
2. National Institutes of Health, Bethesda, MD (United States)

Hair taken from rats dosed with [sup 203]Hg-labeled methylmercury was fed to previously untreated rats in order to determine if the organo-mercurial was available for release from the hair matrix within the gut lumen and for subsequent systemic adsorption. Cumulative fecal excretion data were consistent with an absorption of about 80% of the ingested methylmercury. The relative amounts of methylmercury and of its metabolite, inorganic mercury, in the feces indicated that the percentage of the parent compound released from hair within the intestine equaled or exceeded the estimated bioavailability. Radioactivity in tissues of animals killed 42 hr following hair consumption confirmed that mercury absorption had occurred.

• OSTI ID: 6054773
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 53:12; ISSN 0024-3205; ISSN LIFSAK
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL AVAILABILITY
BODY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELEMENTS
EVEN-ODD NUCLEI
HAIR
HEAVY NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MERCURY
MERCURY 203
MERCURY ISOTOPES
METALS
METHYLMERCURY
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
RODENTS
SKIN
SORPTION
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES