Mutagenicity in Salmonella and sister chromatid exchange in mice for 1,4-, and 1,3-, 2,4-, and 3,4-dimethylphenanthrenes
Journal Article
·
· Environmental and Molecular Mutagenesis; (United States)
- Univ. of Michigan, Ann Arbor (United States)
The mutagenicity in Salmonella and in vivo sister chromatid exchange in the bone-marrow cells of mice was determined for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrene (DMPh) with the objective to study the relative importance of substitution at the 1 and 4 positions of this series of methylated phenanthrenes. For both tests, 1,4-DMPh was decidedly more genotoxic than the remaining regioisomers. While the well recognized role of steric crowding in the bay region is a factor in this enhanced genotoxicity, equally important is substitution at the 1 position with its potential to inhibit detoxication through 9,10-diol formation.
- OSTI ID:
- 6053096
- Journal Information:
- Environmental and Molecular Mutagenesis; (United States), Journal Name: Environmental and Molecular Mutagenesis; (United States) Vol. 17:2; ISSN EMMUE; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
HYDROCARBONS
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTATIONS
ORGANIC COMPOUNDS
PHENANTHRENE
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
HYDROCARBONS
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTATIONS
ORGANIC COMPOUNDS
PHENANTHRENE
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES