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Title: Non-lethal effects of low- and high-LET radiation on cultured mammalian cells

Abstract

In analyzing post-irradiation growth kinetics of cultured mammalian cells, specifically T1-E human cells, this investigation shows that the shift in post-irradiation clone-size distributions toward small colonies is due to both radiation-induced division delay and increased generation times of the irradiated population. Evidence also indicates that the final shape of the final clone-size distribution is influenced by the age density distribution of the parent cells at the time of plating. From computer-generated delay time distributions it was determined that a large percentage of the parent population was found to be in the plateau phase at early growth times and evidence indicates that these cells may contribute heavily to the total population response to radiation.

Authors:
Publication Date:
Research Org.:
Pennsylvania State Univ., University Park (USA)
OSTI Identifier:
6048548
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; CELL CULTURES; BIOLOGICAL RADIATION EFFECTS; AGE DEPENDENCE; BIOPHYSICS; CELL CYCLE; CELL KILLING; DOSE-RESPONSE RELATIONSHIPS; EXTERNAL IRRADIATION; LET; RADIATION DOSES; RADIOSENSITIVITY; BIOLOGICAL EFFECTS; DOSES; ENERGY TRANSFER; IRRADIATION; RADIATION EFFECTS; 560121* - Radiation Effects on Cells- External Source- (-1987); 550300 - Cytology; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Walker, J T. Non-lethal effects of low- and high-LET radiation on cultured mammalian cells. United States: N. p., 1982. Web.
Walker, J T. Non-lethal effects of low- and high-LET radiation on cultured mammalian cells. United States.
Walker, J T. Fri . "Non-lethal effects of low- and high-LET radiation on cultured mammalian cells". United States.
@article{osti_6048548,
title = {Non-lethal effects of low- and high-LET radiation on cultured mammalian cells},
author = {Walker, J T},
abstractNote = {In analyzing post-irradiation growth kinetics of cultured mammalian cells, specifically T1-E human cells, this investigation shows that the shift in post-irradiation clone-size distributions toward small colonies is due to both radiation-induced division delay and increased generation times of the irradiated population. Evidence also indicates that the final shape of the final clone-size distribution is influenced by the age density distribution of the parent cells at the time of plating. From computer-generated delay time distributions it was determined that a large percentage of the parent population was found to be in the plateau phase at early growth times and evidence indicates that these cells may contribute heavily to the total population response to radiation.},
doi = {},
url = {https://www.osti.gov/biblio/6048548}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1982},
month = {1}
}

Thesis/Dissertation:
Other availability
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