Non-lethal effects of low- and high-LET radiation on cultured mammalian cells

Thesis/Dissertation · Fri Jan 01 00:00:00 EST 1982

OSTI ID:6048548

Walker, J T

In analyzing post-irradiation growth kinetics of cultured mammalian cells, specifically T1-E human cells, this investigation shows that the shift in post-irradiation clone-size distributions toward small colonies is due to both radiation-induced division delay and increased generation times of the irradiated population. Evidence also indicates that the final shape of the final clone-size distribution is influenced by the age density distribution of the parent cells at the time of plating. From computer-generated delay time distributions it was determined that a large percentage of the parent population was found to be in the plateau phase at early growth times and evidence indicates that these cells may contribute heavily to the total population response to radiation.

• Research Organization: Pennsylvania State Univ., University Park (USA)
• OSTI ID: 6048548
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CELL CULTURES
BIOLOGICAL RADIATION EFFECTS
AGE DEPENDENCE
BIOPHYSICS
CELL CYCLE
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
LET
RADIATION DOSES
RADIOSENSITIVITY
BIOLOGICAL EFFECTS
DOSES
ENERGY TRANSFER
IRRADIATION
RADIATION EFFECTS
560121* - Radiation Effects on Cells- External Source- (-1987)
550300 - Cytology
550603 - Medicine- External Radiation in Therapy- (1980-)