Quantitative SPECT reconstruction of iodine-123 data
- Duke Univ. Medical Center, Durham, NC (USA)
Many clinical and research studies in nuclear medicine require quantitation of iodine-123 ({sup 123}I) distribution for the determination of kinetics or localization. The objective of this study was to implement several reconstruction methods designed for single-photon emission computed tomography (SPECT) using {sup 123}I and to evaluate their performance in terms of quantitative accuracy, image artifacts, and noise. The methods consisted of four attenuation and scatter compensation schemes incorporated into both the filtered backprojection/Chang (FBP) and maximum likelihood-expectation maximization (ML-EM) reconstruction algorithms. The methods were evaluated on data acquired of a phantom containing a hot sphere of {sup 123}I activity in a lower level background {sup 123}I distribution and nonuniform density media. For both reconstruction algorithms, nonuniform attenuation compensation combined with either scatter subtraction or Metz filtering produced images that were quantitatively accurate to within 15% of the true value. The ML-EM algorithm demonstrated quantitative accuracy comparable to FBP and smaller relative noise magnitude for all compensation schemes.
- OSTI ID:
- 6042239
- Journal Information:
- Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:3; ISSN 0161-5505; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
655003* -- Medical Physics-- Dosimetry
ACCURACY
ALGORITHMS
ATTENUATION
BETA DECAY RADIOISOTOPES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
MATHEMATICAL LOGIC
MOCKUP
NUCLEI
ODD-EVEN NUCLEI
PHANTOMS
RADIOISOTOPES
SCATTERING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
TOMOGRAPHY