Single high dose intraoperative electrons for advanced stage pancreatic cancer: Phase I pilot study
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Phase I toxicity studies with intraoperative radiotherapy proved to be a feasible adjunct to surgery for unresectable malignancies of the pancreas at Howard University Hospital. There have been minimal side effects or complications related to the combination of limited surgical decompression and intraoperative radiotherapy alone. The toxic effects of intraoperative radiotherapy on normal tissues is being assessed on a dose volume basis. Doses of 2000 to 2500 rad in a single exposure to include the pancreas, regional nodes and duodenum are acceptable if the total treatment volume is less than or equal to 100 cm. The tumoricidal effects on the cancer are demonstratable when one reviews the pathological specimens that illustrate massive tumor necrosis and fibros replacement, but in all cases reviewed, viable cancer was noted. Intraoperative radiotherapy, therefore, represents a significant boost dose for resectable, partially resectable or non-resectable tumors when added to conventional external beam irradiation and/or chemotherapy. Preliminary clinical data and minimal toxicity justifies further investigation.
- Research Organization:
- Howard Univ. Hospital, Washington, DC
- OSTI ID:
- 6042148
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:7; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOREXIA
BODY
DIGESTIVE SYSTEM
ELECTRONS
ELEMENTARY PARTICLES
ENDOCRINE GLANDS
ENERGY RANGE
FERMIONS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
LARGE INTESTINE
LEPTONS
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
MEV RANGE
MEV RANGE 01-10
MEV RANGE 10-100
NAUSEA
NECROSIS
NUCLEAR MEDICINE
ORGANS
PANCREAS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SYMPTOMS
THERAPY
ULCERS
VOMITING
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOREXIA
BODY
DIGESTIVE SYSTEM
ELECTRONS
ELEMENTARY PARTICLES
ENDOCRINE GLANDS
ENERGY RANGE
FERMIONS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
LARGE INTESTINE
LEPTONS
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
MEV RANGE
MEV RANGE 01-10
MEV RANGE 10-100
NAUSEA
NECROSIS
NUCLEAR MEDICINE
ORGANS
PANCREAS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SYMPTOMS
THERAPY
ULCERS
VOMITING