Validation and application of pharmacokinetic models for interspecies extrapolations in toxicity-risk assessments of volatile organics. Final report, 1 Jul 87-30 Apr 91
Technical Report
·
OSTI ID:6037958
Direct measurements of perchloroethylene (PER), trichloroethylene (TCE), trichloroethane (TRI) and dichloroethylene (DCE) were made in the blood and exhaled breath of rats during and following inhalation exposures. The pharmacokinetics of these four halocarbons were also investigated following oral administration. An accurate assay for measuring volatile halogenated hydrocarbons in a variety of body tissues was developed and demonstrated for PER, TCE, TRI, and tetrachloroethane (TET). The tissue concentration-time profiles and bioavailability for PER and TET were determined in liver, kidney, brain, fat, lung, heart, and muscle tissues following oral and intraarterial administrations in rats. Interspecies comparisons of the pharmacokinetics of PER and TET were made following oral and intraarterial administrations in two species: Sprague-Dawley rats and Beagle dogs. Neurobehavioral determinations were conducted in rats following inhalation exposures, single oral bolus administration, and gastric infusion of PER.
- Research Organization:
- Georgia Univ., Athens, GA (United States). Dept. of Pharmacology and Toxicology
- OSTI ID:
- 6037958
- Report Number(s):
- AD-A-240058/8/XAB; CNN: AFOSR-87-0248
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCURACY
ANIMALS
BEAGLES
BEHAVIOR
BIOLOGICAL AVAILABILITY
BIOLOGICAL MODELS
CHLORINATED ALIPHATIC HYDROCARBONS
DISTRIBUTION
DOGS
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MEASURING METHODS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
RISK ASSESSMENT
RODENTS
TESTING
TISSUE DISTRIBUTION
TOXICITY
VALIDATION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCURACY
ANIMALS
BEAGLES
BEHAVIOR
BIOLOGICAL AVAILABILITY
BIOLOGICAL MODELS
CHLORINATED ALIPHATIC HYDROCARBONS
DISTRIBUTION
DOGS
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MEASURING METHODS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
RISK ASSESSMENT
RODENTS
TESTING
TISSUE DISTRIBUTION
TOXICITY
VALIDATION
VERTEBRATES