Validation and application of pharmacokinetic models for interspecies extrapolations in toxicity risk assessments of volatile organics. Annual report No. 2, 1 July 1988-30 June 1989
Technical Report
·
OSTI ID:5404805
In pursuit of the goal of establishing a scientific basis for the interspecies extrapolation of pharmacokinetic data in health-risk assessments, a series of studies were conducted involving pharmacokinetic determinations in rats to several aliphatic halocarbons (with parallel studies initiated in the dog). Direct measurements of the uptake and elimination of halocarbon in rats were completed during the following inhalation exposures and following oral administration of dichloroethylene (DCE) and perchloroethylene (PCE). An assay for the measurement of halocarbons in the tissues of exposed animals has been successfully developed, and tissue-concentration profiles in the liver, kidney, lung, fat, brain, muscle, and heart were completed for oral and intraarterial administrations of PCE. The utility of the physiologically-based pharmacokinetic model for the accurate computer simulations of the pharmacokinetics of three halocarbons with wide variation in physicochemical properties (TRI, TCE, and PCE) has been demonstrated.
- Research Organization:
- Georgia Univ., Athens, GA (USA)
- OSTI ID:
- 5404805
- Report Number(s):
- AD-A-211270/4/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCURACY
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED SIMULATION
DATA
DIGESTIVE SYSTEM
DOCUMENT TYPES
DOGS
EXPERIMENTAL DATA
EXTRAPOLATION
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
INFORMATION
INHALATION
INTAKE
LIVER
LUNGS
MAMMALS
MATTER
METABOLISM
NERVOUS SYSTEM
NUMERICAL DATA
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHARMACOLOGY
PROGRESS REPORT
RATS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SIMULATION
TESTING
TOXICITY
VALIDATION
VARIATIONS
VERTEBRATES
VOLATILE MATTER
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCURACY
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED SIMULATION
DATA
DIGESTIVE SYSTEM
DOCUMENT TYPES
DOGS
EXPERIMENTAL DATA
EXTRAPOLATION
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
INFORMATION
INHALATION
INTAKE
LIVER
LUNGS
MAMMALS
MATTER
METABOLISM
NERVOUS SYSTEM
NUMERICAL DATA
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHARMACOLOGY
PROGRESS REPORT
RATS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SIMULATION
TESTING
TOXICITY
VALIDATION
VARIATIONS
VERTEBRATES
VOLATILE MATTER