Response to deep hypoglycemia does not involve glucoreceptors in carotid perfused tissue

Journal Article · Tue Nov 01 00:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6037083

Cane, P; Haun, C K; Evered, J; Youn, J H; Bergman, R N ^[1]

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1. Univ. of Southern California, Los Angeles (USA)

In the present study the authors examined whether the magnified hormonal counter-regulatory response seen during deep hypoglycemia (40 mg/dl) could be attenuated by supplying the forebrain with glucose furnished through carotid infusion. Two protocols were performed in conscious dogs. In the first protocol they infused glucose bilaterally into the carotid circulation to produce a forebrain glycemia of 55 {plus minus} 1 mg/dl whereas systemic glycemia declined to 39 {plus minus} 2 mg/dl. In the second protocol as a control they infused glucose into the systemic circulation at a rate matched to protocol 1 so that both systemic and jugular plasma glucose concentrations were equivalent to the systemic glucose concentrations in protocol 1. In spite of a substantial difference in forebrain glycemia there were no differences in the counter-regulatory responses of catecholamines or glucagon. In addition, through the use of radiolabeled microspheres, they defined the precise regions of the forebrain irrigated during bilateral intracarotid glucose infusions. The concentration of microspheres was high in the forebrain but very low in the hindbrain. The results indicate that glucoreceptor cells in tissues perfused by carotid arteries may play a tautological role in the sympathetic response to hypoglycemia and imply that glucose-sensitive receptors must also be located elsewhere in the central nervous system or in the periphery.

• OSTI ID: 6037083
• Journal Information: American Journal of Physiology; (USA), Vol. 255:5; ISSN 0002-9513
• Country of Publication: United States
• Language: English

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