New type of genome instability in Drosophila melanogaster
During crossing of two stable laboratory lines, y/sup 2/sc/sup 1w/sup aG// and Df(1)Pgd-kz/FM4, y/sup 31d/sc/sup 8/dm B, consistent instability originated reproducibly in progeny containing a y/sup 2/sc/sup 1/w/sup aG/ chromosome and autosomes of both lines. It is expressed in active mutagenesis observed over the course of several tens of generations. Destabilization occurs independently of direction of crossing. Mutagenesis occurs both in somatic and in sex cells of males and females. It displays high locus specificity. A transpositional nature was shown for at least some of the mutations. Results of the experiments concerning hybridization in situ with different mobile elements indicates an absence or low frequency of tranpositional bursts in the system. Possible mechanisms of induction of genetic instability in the system described are discussed.
- Research Organization:
- N.I. Vavilov Institute of General Genetics, Moscow (USSR)
- OSTI ID:
- 6036604
- Journal Information:
- Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 24:5; ISSN SOGEB
- Country of Publication:
- United States
- Language:
- English
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550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ARTHROPODS
CHROMOSOMES
CROSSING-OVER
DIPTERA
DNA
DNA SEQUENCING
DOMINANT MUTATIONS
DROSOPHILA
FEMALES
FLIES
FRUIT FLIES
GENETIC MAPPING
GENOME MUTATIONS
GENOTYPE
HETEROCHROMOSOMES
HYBRIDIZATION
INSECTS
INSTABILITY
INVERTEBRATES
LABELLED COMPOUNDS
MALES
MAPPING
MOBILITY
MOSAICISM
MUTAGENESIS
MUTANTS
MUTATION FREQUENCY
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROGENY
RADIOASSAY
RECESSIVE MUTATIONS
RECOMBINANT DNA
REVERTANTS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TRITIUM COMPOUNDS
X CHROMOSOME
Y CHROMOSOME