Genetic instability of the lozenge locus in Drosophila melanogaster: Characterization of the lz{sup 75V} allele
- Inst. of Cytology and Genetics, Novosibirsk (Russian Federation)
Genetic properties of lz{sup 75V}, an unstable allele of the lozenge locus, are described. The lz{sup 75V} allele appeared in progeny of a male from a Far East natural population of Drosophila melanogaster. Mutation of this allele produces a broad spectrum of mutant derivatives with phenotypes varying from normal to extreme. The arising alleles can be stable or unstable. Some lz{sup 75V} derivatives continuously preserve their spontaneous mutability in laboratory conditions, whereas other alleles of the same family show progressive stabilization at the intralocus or intrachromosome level. Instability of the lz{sup 75V}-bearing X chromosome is locus-specific: only the lozenge gene mutates with high frequency, while visible mutations at other loci rarely occur. As shown previously, the lz{sup 75V} allele appears to be caused by a P-element insertion. The appearance of spontaneous instability is discussed with regard to the general problem of transposition regulation in mobile elements. Different systems of hybrid dysgenesis, and, in particular, P elements are assumed to play an important role in induction of unstable mutations in nature. 24 refs., 5 tabs.
- OSTI ID:
- 241016
- Journal Information:
- Russian Journal of Genetics, Journal Name: Russian Journal of Genetics Journal Issue: 12 Vol. 31; ISSN 1022-7954; ISSN RJGEEQ
- Country of Publication:
- United States
- Language:
- English
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