Genetic analysis of the claret locus of Drosophila melanogaster
- Pennsylvania State Univ., Hershey (USA)
The claret (ca) locus of Drosophila melanogaster comprises two separately mutable domains, one responsible for eye color and one responsible for proper disjunction of chromosomes in meiosis and early cleavage divisions. Previously isolated alleles are of three types: (1) alleles of the claret (ca) type that affect eye color only, (2) alleles of the claret-nondisjunctional (ca{sup nd}) type that affect eye color and chromosome behavior, and (3) a meiotic mutation, non-claret disjunctional (ncd), that affects chromosome behavior only. In order to investigate the genetic structure of the claret locus, the authors have isolated 19 radiation-induced alleles of claret on the basis of the eye color phenotype. Two of these 19 new alleles are of the ca{sup nd} type, while 17 are of the ca type, demonstrating that the two domains do not often act as a single target for mutagenesis. This suggests that the two separately mutable functions are likely to be encoded by separate or overlapping genes rather than by a single gene. One of the new alleles of the ca{sup nd} type is a chromosome rearrangement with a breakpoint at the position of the claret locus. If this breakpoint is the cause of the mutant phenotype and there are no other mutations associated with the rearrangement, the two functions must be encoded by overlapping genes.
- OSTI ID:
- 6701744
- Journal Information:
- Genetics; (USA), Journal Name: Genetics; (USA) Vol. 123:3; ISSN 0016-6731; ISSN GENTA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CELL DIVISION
CHROMOSOMAL ABERRATIONS
COBALT 60
COBALT ISOTOPES
COLOR
DIPTERA
DROSOPHILA
ELECTROMAGNETIC RADIATION
EYES
FACE
FLIES
FRUIT FLIES
GAMMA RADIATION
GENE MUTATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEAD
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEIOSIS
MINUTES LIVING RADIOISOTOPES
MUTAGENESIS
MUTATIONS
NUCLEI
ODD-ODD NUCLEI
OPTICAL PROPERTIES
ORGANOLEPTIC PROPERTIES
ORGANS
PHENOTYPE
PHYSICAL PROPERTIES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
SENSE ORGANS
YEARS LIVING RADIOISOT