Effect of ozone on acid hydrolases of the pulmonary alveolar macrophage

Journal Article · Wed Dec 31 23:00:00 EST 1969 · RES, J. Reticuloendothel. Soc.; (United States)

OSTI ID:6036124

Hurst, D J; Gardner, D E; Coffin, D L

Dose-related decrease was noted in intracellular activities of acid phosphatase, ..beta..-glucuronidase, and lysozyme of macrophages lavaged from rabbits exposed to 0.25 to 7.0 ppM O/sub 3/ for 3 hours. Enzyme levels returned to near-normal 24 hour post-exposure. Lysozyme was reduced most; ..beta..-glucuronidase, least. Lysosomal fraction lost activity while supernatant gained, indicating some effect on membranes.

• OSTI ID: 6036124
• Journal Information: RES, J. Reticuloendothel. Soc.; (United States), Journal Name: RES, J. Reticuloendothel. Soc.; (United States) Vol. 8; ISSN RESJA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ENZYMES
ESTERASES
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROLASES
LUNGS
LYSOZYME
MACROPHAGES
MAMMALS
ORGANS
OZONE
PHAGOCYTES
PHOSPHATASES
RABBITS
RESPIRATORY SYSTEM
SOMATIC CELLS
TISSUE CULTURES
TOXICITY
VERTEBRATES