Synthesis, structure, and properties of pyrazolo(4,3-b)quinuclidine derivatives
Journal Article
·
· Chem. Heterocycl. Compd. (Engl. Transl.); (United States)
OSTI ID:6033887
It was shown by means of /sup 1/H and /sup 13/C NMR spectroscopy that the reaction of 2-arylmethylene-3-oxoquinuclidines with hydrazine hydrate gives 4a-hydroxy-7-aryl-4a,5,7,7a-tetrahydropyrazolo(4,3-b)quinuclidines, which are stable in the crystalline state but undergo dehydration to the corresponding 7-aryl-6H-7,7a-dihydropyrazolo(4,3-b)quinuclidines in solutions. The latter undergo cleavage to 3-(4-piperidyl)-5-arylpyrazoles when they are heated in an alkaline medium.
- Research Organization:
- S. Ordzhonikidze, All-Union Scientific-Research Institute of Pharmaceutical Chemistry, Moscow, USSR
- OSTI ID:
- 6033887
- Journal Information:
- Chem. Heterocycl. Compd. (Engl. Transl.); (United States), Journal Name: Chem. Heterocycl. Compd. (Engl. Transl.); (United States) Vol. 21:9; ISSN CHCCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AROMATICS
AZAARENES
AZINES
AZOLES
CARBON 13
CARBON ISOTOPES
CHEMICAL REACTIONS
CONFORMATIONAL CHANGES
COUPLING
COUPLING CONSTANTS
DEHYDROCYCLIZATION
DISSOCIATION
ELECTRONIC STRUCTURE
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYBRIDIZATION
HYDRATES
HYDRAZINE
HYDROGEN 1
HYDROGEN ISOTOPES
HYPERFINE STRUCTURE
INFRARED SPECTRA
INTERMEDIATE COUPLING
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MOLECULAR STRUCTURE
NITROGEN COMPOUNDS
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRAZOLES
PYRIDINES
QUINOLINES
SPECTRA
STABILITY
STABLE ISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TEMPERATURE EFFECTS
400201* -- Chemical & Physicochemical Properties
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AROMATICS
AZAARENES
AZINES
AZOLES
CARBON 13
CARBON ISOTOPES
CHEMICAL REACTIONS
CONFORMATIONAL CHANGES
COUPLING
COUPLING CONSTANTS
DEHYDROCYCLIZATION
DISSOCIATION
ELECTRONIC STRUCTURE
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYBRIDIZATION
HYDRATES
HYDRAZINE
HYDROGEN 1
HYDROGEN ISOTOPES
HYPERFINE STRUCTURE
INFRARED SPECTRA
INTERMEDIATE COUPLING
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MOLECULAR STRUCTURE
NITROGEN COMPOUNDS
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRAZOLES
PYRIDINES
QUINOLINES
SPECTRA
STABILITY
STABLE ISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TEMPERATURE EFFECTS