15-(p-(/sup 75/Br)bromophenyl) pentadecanoic acid: pharmacokinetics and potentialas heart agent

Journal Article · Thu Oct 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:6025521

Coenen, H H; Harmand, M F; Kloster, G; Stocklin, G

Preparation, quality control, and pharmacokinetics of 15-(p-(/sup 75/Br)bromophenyl)-pentadecanoic acid (BPPA) were studied, with particular emphasis on the fate of the label and the usefulness of BPPA as a heart agent. BPPA labeled with the positron emitter Br-75 (T/sub 1/2/ = 98 min) was prepared in 55% radiochemical yield with a specific activity of greater than or equal to 1000 Ci/mmol. While the uptake of BPPA in the heart muscle is as fast and efficient as that of aliphatic ..cap alpha..-halofatty acids, its elimination is delayed, owing mainly to an inhibited ..beta.. oxidation and the formation of lipophillic catabolites. The blood activity and its time course are identical to those of ..cap alpha..-halofatty acids, but no free bromide appears in any body fluid or organ. The complex pharmacokinetic behavior of stable lipophilic catabolites prevents a quantitative background correction. In contrast to aliphatic ..cap alpha..-halofatty acids, a quantitative evaluation of myocardial metabolism is not possible. Br-75 BPPA, however, is well suited for positron emission tomography of the heart.

• Research Organization: Kernforschungsanlage, Juelich, West Germany
• OSTI ID: 6025521
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE 75
BROMINE ISOTOPES
CARBOXYLIC ACID ESTERS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTERS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
TOMOGRAPHY
UPTAKE