Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Terbinafine: effects on platelet-derived growth factor-stimulated smooth muscle cells in vitro and myointimal proliferation in vivo

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:6023247
; ; ; ; ; ;
Terbinafine (T; (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine), an antimycotic agent with antimitogenic activity in fibroblasts, was examined for its effects on platelet-derived growth factor (PDGF)-stimulated aortic smooth muscle cell DNA synthesis in vitro and myointimal proliferation in vivo. Exposure of smooth muscle cells to 1-25 ..mu..M T resulted in a concentration-dependent inhibition of PDGF-induced mitogenesis as determined by (/sup 3/H)thymidine incorporation or cell number. The IC/sub 50/ for T was approximately 5 ..mu..M. The inhibitory effect of terbinafine persisted in the presence of 0.4-8.0 ..mu..g/ml cholesterol or 130 ..mu..g/ml mevalonate. Administration of T to rats for 2 d before and 14 d after balloon catheter carotid injury resulted in a 40% decrease in lesion area. These observations indicate that T is both a potent in vitro antagonist of the smooth muscle cell mitogenic response to PDGF and an effective, well-tolerated, orally active inhibitor of myointimal proliferation in vivo.
Research Organization:
Sandoz Research Institute, East Hanover, NJ
OSTI ID:
6023247
Report Number(s):
CONF-870644-
Conference Information:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 46:6
Country of Publication:
United States
Language:
English

Similar Records

Inhibition of the mitogenic response to platelet-derived growth factor by terbinafine
Conference · Fri May 01 00:00:00 EDT 1987 · Federation Proceedings, Federation of American Societies for Experimental Biology; (USA) · OSTI ID:5030118
Stimulation of aortic smooth muscle cell mitogenesis by serotonin
Journal Article · Fri Jan 31 23:00:00 EST 1986 · Proc. Natl. Acad. Sci. U.S.A.; (United States) · OSTI ID:6470123
Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling
Journal Article · Fri Oct 19 00:00:00 EDT 2012 · Biochemical and Biophysical Research Communications · OSTI ID:22210295

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AZINES
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
FIBROBLASTS
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
IN VITRO
IN VIVO
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MITOGENS
MUSCLES
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIMIDINES
RATS
RIBOSIDES
RODENTS
SOMATIC CELLS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES