Serial PET studies of human cerebral malignancy with (1-/sup 11/C)putrescine and (1-/sup 11/C)2-deoxy-D-glucose

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6022065

Hiesiger, E; Fowler, J S; Wolf, A P; Logan, J; Brodie, J D; McPherson, D; MacGregor, R R; Christman, D R; Volkow, N D; Flamm, E

Serial PET measurements of (1-/sup 11/C)putrescine ((/sup 11/C)PUT) uptake and glucose metabolic rate (GMR) using (1-/sup 11/C)2-deoxy-D-glucose ((/sup 11/C)2DG) were made on eight human subjects with a radiological and, in most cases, pathological diagnosis of primary or metastatic brain tumor. Blood-to-brain influx constants (Ki) were calculated for (/sup 11/C)PUT. Tumor uptake of /sup 11/C after (/sup 11/C)PUT injection was unidirectional peaking at 15 min. The mean +/- s.d. Kis for (/sup 11/C)PUT for tumor and normal brain tissue were 0.78 +/- 0.045 and 0.024 +/- 0.007 ml cc-1 min-1, respectively (average of ratio, 3.11 whereas the ratio of GMR for tumor and normal brain tissue was 1.2 +/- 0.5. The mean Ki for four active, high grade astrocytomas was 0.098 +/- 0.030 in contrast to 0.027 +/- 0.008 ml cc-1 min-1 for two patients with low grade astrocytoma. Active high grade astrocytomas also showed marked CT contrast enhancement and regional glucose hypermetabolism. In one subject with brain metastases, both (/sup 11/C)PUT and GMR correlated with a declining clinical picture in repeated studies over a 4-mo period. PET studies with (/sup 11/C)PUT provide a better signal:noise ratio than GMR measurements, are useful for locating small glycolytically hypometabolic tumors and, when used in longitudinal studies in a single subject, appear to provide an index of degree of malignancy.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 6022065
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
METASTASES
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PUTRESCINE
RADIOISOTOPES
SACCHARIDES
SIGNAL-TO-NOISE RATIO
TOMOGRAPHY
VERTEBRATES