Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets

Conference · Mon Feb 26 00:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6011814

Pandey, S C; Davis, J M; Schwertz, D; Pandey, G N ^[1]

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1. Illinois State Psychiatric Inst., Chicago (United States)

The authors previously reported that tricyclic antidepressants and iprindole inhibit thrombin-stimulated formation of inositol-1, 4 bisphosphate (IP2) and inositol-1,4,5 triphosphate (IP3) but do not cause any change in inositol-1 phosphate (IP1). In order to examine if this decrease in IP2 and IP3 formation by antidepressants is related to the inhibition of the enzyme phospholipase C (PLC), the authors determined the effects of antidepressants and neuroleptics on the levels of 3(H) phosphotidylinositol (PI), 3(H) PI-4 phosphate (PIP), 3(H) PI-4, 5 bisphosphate (PIP2) in human platelets. The implications of the findings and their relevance to the mode of action of antidepressants are discussed.

• OSTI ID: 6011814
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
PSYCHOTROPIC DRUGS
BLOOD PLATELETS
HYDROLASES
INOSITOLS
MAN
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ENZYMES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MATERIALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
REACTION KINETICS
SACCHARIDES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques