Perinatal upregulation of intestinal transport of carnitine (C) in newborn pigs

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6011631

Li, B U.K.; Murray, R D; Heitlinger, L A; McClung, H J; Hughes, A M; O'Dorisio, T M; Sloan, H R ^[1]

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1. Columbus Children's Hospital, OH (United States) Ohio State Univ., Columbus (United States)

Since C facilitates the perinatal transition from carbohydrate to lipid-derived energy, the authors examined the contribution of intestinal transport of dietary C to this process by determining (C)'s in sow's milk, pig jejunum and liver, and C flux across the jejunum (J{sub m-s}) as a function of postnatal age. The authors measured portal venous glucagon (G) and insulin (l) as potential regulatory signals and attempted to alter intestinal transport of C by infusing G. Pigs at days 1-7 (NB-newborn), 14-16 (SU-suckling) and 33-35 (WN-weanling) were studied. (C)'s in sow milk, piglet jejunum, and liver were determined. Fluxes were measured in an Ussing chamber and in an in situ recirculating jejunal perfusion. The effect of an IV infusion of G on ({sup 3}H)C absorption was evaluated in a single animal; an adjacent jejunal segment received saline. Sow's milk and liver (C)'s, and jejunal C transport were highest following birth and declined towards weaning. Plasma (G) and the G:I ratio demonstrated a parallel temporal pattern. The G-stimulated jejunal segment removed 53% of the C and the non-stimulated control segment, 8%. It was concluded that during the perinatal metabolic transition, enhanced intestinal nutrient assimilation promotes the transfer of dietary C to the liver where it could facilitate fatty acid oxidation. This pattern of upregulated intestinal transport immediately after birth may be mediated by pancreatic G and I secretion.

• OSTI ID: 6011631
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARNITINE
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
FOOD
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
HYDROXY ACIDS
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
LIVER
MAMMALS
MATERIALS
METABOLISM
MILK
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDATION
REACTION KINETICS
SMALL INTESTINE
SWINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
VITAMIN B GROUP
VITAMINS