Ontogeny and site of intestinal lipid and lipoprotein synthesis
Conference
·
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:6061828
- Univ. de Montreal, Quebec (Canada)
The cellular mechanisms leading to the formation of intestinal lipoproteins remain obscure. Our objective was to determine the ontogeny of intestinal lipoprotein synthesis in the jejunum and ileum. Explants of jejunum and ileum from suckling (5 d) and weanling (23 d) were cultured in the presence of {sup 14}C-oleic acid to examine lipid synthesis (DPM/mg protein). Incorporation of oleate by jejunum and ileum was significantly increased for the weanling compared to suckling rats. Triglyceride synthesis followed the same pattern, but only for the jejunum, whereas the latter group's jejunal cultures produce more VLDL-TG. The incorporation of {sup 14}C-oleate as a function of site revealed increased uptake by ileum compared to jejunum by 24% and 36% for weanling and suckling groups respectively. Furthermore, at the suckling period synthesis of TG, CM-TG and VLDL-TG was similar for jejunum and ileum explants, whereas it was elevated at the jejunum compared to the ileum for the weaning period. Our findings show important changes that occur in lipid and lipoprotein synthesis during development, and that differences exist between ileum and jejunum. The modification may be influenced by alterations known to occur during this period.
- OSTI ID:
- 6061828
- Report Number(s):
- CONF-9104107--
- Conference Information:
- Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
ESTERS
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ONTOGENESIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SMALL INTESTINE
SYNTHESIS
TISSUES
TRACER TECHNIQUES
TRIGLYCERIDES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
ESTERS
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ONTOGENESIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SMALL INTESTINE
SYNTHESIS
TISSUES
TRACER TECHNIQUES
TRIGLYCERIDES
VERTEBRATES