Enantioselective solvent extraction of neutral DL-amino acids in two-phase systems containing N-n-alkyl-L-proline derivatives and copper(II) ion

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00271a022· OSTI ID:6011241

Takeuchi, T; Horikawa, R; Tanimura, T

Distribution behavior of neutral amino acid enantiomers was examined in the aqueous and organic solvent of a two-phase system containing cupric ion and N-n-dodecyl-L-proline or N-n-alkyl-L-hydroxyproline. Significant enantioselectivity was observed when n-butyl, n-amyl, or n-octyl alcohol was used as the organic solvent. Equilibrium constants of ligand exchange reaction for several amino acid enantiomers were estimated for the n-butyl alcohol-water system. The enantioselectivity seems to depend primarily on the difference of the stability of mixed ligand complexes in the organic phase. 14 references, 2 figures, 3 tables.

• Research Organization: Toyama Medical Pharmaceutical Univ., Japan
• OSTI ID: 6011241
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 56:7; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400105* -- Separation Procedures
ABSORPTION SPECTROSCOPY
AMINES
AMINO ACIDS
AZOLES
CARBOXYLIC ACIDS
CHEMICAL REACTION KINETICS
CHROMATOGRAPHY
COPPER COMPOUNDS
DATA
EMISSION SPECTROSCOPY
ENANTIOMORPHS
EXPERIMENTAL DATA
EXTRACTION
FLUORESCENCE SPECTROSCOPY
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
KINETICS
LIQUID COLUMN CHROMATOGRAPHY
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PH VALUE
PROLINE
PYRROLES
PYRROLIDINES
REACTION KINETICS
SEPARATION PROCESSES
SOLVENT EXTRACTION
SOLVENT PROPERTIES
SPECTROSCOPY
TRANSITION ELEMENT COMPOUNDS