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Response of lymphosarcoma LS/BL cells to continuous irradiation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576418· OSTI ID:6004239
;
Mouse lymphosarcoma LS/BL cells growing as an ascites tumor in the peritoneal cavity of C57BL mice were continuously irradiated in vivo at a low exposure rate of 1.2 Gy per day (5 rad/hr). The growth of the ascites tumor evaluated by direct counting of the cells in the peritoneal cavity and their capacity to form colonies in livers declined with increasing time of continuous irradiation. The radiosensitivity and repair ability of LS/BL cells were studied by a serial dilution method using host survival time as the end point and by the liver colony assay. The radiosensitivity of continuously irradiated LS/BL-CI cells showed no remarkable change as measured by the D/sub 0/ values, but from the 150th week of irradiation the inital shoulder on the survival curves appeared and its width increased with time of exposure. The extrapolation number (n) increased from 1.0 to 8.4 after 350 weeks of irradiation. The reappearance of the initial shoulder was proved with the split-dose technique.
Research Organization:
Inst. of Biophysics, Brno, Czechoslovakia
OSTI ID:
6004239
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
CHRONIC EXPOSURE
CHRONIC IRRADIATION
COLONY FORMATION
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LYMPHOMAS
LYMPHOSARCOMAS
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SARCOMAS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION