Serial Ga-67 citrate imaging in children with neoplastic disease: concise communication

Journal Article · Thu Mar 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:6001525

Yang, S L; Alderson, P O; Kaizer, H A; Wagner, Jr, H N

To investigate the role of Ga-67 imaging in children with neoplastic disease, 83 Ga-67 scans, obtained in 46 children with neoplastic disease, were retrospectively analyzed. The series included 19 children who had two to five serial Ga-67 scans while undergoing therapy over periods as long as 4 y. Three patterns were identified in the children who had serial Ga-67 imaging: (a) twelve children with tumors that were initially gallium-avid had normal scans after chemotherapy and/or radiotherapy; (b) four children had persistently positive Ga-67 scans while being treated; and (c) three children with gallium-avid tumors developed a normal scan after therapy, but later had a gallium-avid recurrence. All 12 children in the first group were alive and clinically disease-free after a mean followup time of 38 months. Six of the seven children with persistently gallium-avid tumors or gallium-avid recurrent tumors died during a mean followup time of 15.5 months. The results of this small series suggest that further investigation is warranted to determine whether the results of serial Ga-67 imaging have any prognostic significance in children with neoplastic disease.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 6001525
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
CHEMOTHERAPY
CHILDREN
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
VERTEBRATES