Role of $sup 67$Ga citrate scanning in the management of non-Hodgkin's lymphoma

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Cancer, v. 36, no. 5, pp. 1690-1701

OSTI ID:4128213

Levi, J A; O'Connell, M J; Murphy, W L; Sutherland, J C; Wiernik, P H

Gallium-67 scans were performed as part of the initial evaluation in 45 patients with non-Hodgkin's lymphoma. Eighteen of these patients underwent staging laparotomy and splenectomy. In addition, scans were performed either shortly after therapy was completed or during subsequent followup in 10 patients. The initial scans were found most useful for patients with histiocytic lymphoma: in detecting sites of involvement above the diaphragm and the high para-aortic/ mesenteric region, and when tumors were greater than 2 cm in diameter. The addition of $sup 67$Ga scanning to the pre-operative clinical evaluation reduced the number of incorrectly staged patients from 8 to 4. Reversion of previously positive $sup 67$Ga scans to negative in 3 patients with suspected persistent or recurrent disease was associated with fibrosis and no lymphoma when biopsied. Five other patients had histologically documented positive $sup 67$Ga scans post- therapy; in 1 the $sup 67$Ga scan was only definitive noninvasive procedure. Despite the occurrence of both false-positive and false-negative $sup 67$Ga scans, this procedure appears to be a useful supplement to the pretreatment evaluation of patients with non-Hodgkin's lymphoma, especially the histiocytic form. Confirmation of its ability to detect high para-aortic/mesenteric involvement may subsequently result in a reduction of the number of staging laparotomies necessary. For the post-treatment followup of these patients $sup 67$Ga scans may prove to be a valuable noninvasive investigation. (auth)

• Research Organization: National Cancer Inst., Baltimore
• NSA Number: NSA-33-009721
• OSTI ID: 4128213
• Journal Information: Cancer, v. 36, no. 5, pp. 1690-1701, Journal Name: Cancer, v. 36, no. 5, pp. 1690-1701; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

*GALLIUM 67-- SCINTISCANNING
*LYMPHOMAS-- DIAGNOSIS
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
CITRATES
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
PATIENTS