Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.81.15.4874· OSTI ID:6000822

Zabel, B U; Fournier, R E.K.; Lalley, P A; Naylor, S L; Sakaguchi, A Y

Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes (viral (v) erb-A and erb-B). Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridication techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 ..-->.. qter) and located c-erb-B on human chromosome 7 (7pter ..-->.. q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11. 38 references, 4 figures, 1 table.

• Research Organization: Roswell Park Memorial Inst., Buffalo, NY
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6000822
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 81:15; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGY
BIRDS
CHICKENS
CHROMOSOMES
DISEASES
DNA SEQUENCING
FOWL
GENES
GENETIC MAPPING
GENETICS
HYBRIDIZATION
INFECTIOUS DISEASES
MAMMALS
MAN
MAPPING
MICE
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
PRIMATES
RODENTS
SARCOMAS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRAL DISEASES