Phospholipase C {gamma}-2 (Plcg2) and phospholipase C {gamma}-1 (Plcg1) map to distinct regions in the human and mouse genomes
- Thomas Jefferson Univ., Philadelphia, PA (United States); and others
The phospholipase C {gamma}-2 (Plcg2) gene encodes an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate. We have now determined the chromosomal location of this gene in the mouse and human genomes. An interspecific backcross involving AEJ/Gn and Mus spretus mice was used to localize the gene in mouse. A rodent/human somatic cell hybrid panel was used to map PLCG2 in the human genome. Our results position Plcg2 in the central region of mouse chromosome 8. We also show that PLCG2 maps to the long arm of human chromosome 16, in the region q22-qter. Plcg2 does not map near its most closely related family member, Plcg1, in either genome, indicating that the mammalian Plcg genes belong to a dispersed family. 29 refs., 3 figs., 2 tabs.
- OSTI ID:
- 241063
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
Similar Records
The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively
Genetic mapping of the adenine nucleotide translocase-2 gene (Ant2) to the mouse proximal X chromosome