Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-{gamma}2 in the human and the mouse
- St. Mary`s Hospital Medical School, London (United Kingdom)
- The Hospital for Sick Children, Toronto, Ontario (Canada)
The authors have mapped the PLCG2 gene, which encodes the enzyme phosphatidyl inositol-specific phospholipase C-{gamma}2. This is one of the phospolipases responsible for catalyzing the hydrolysis of phosphatidyl inositol in response to a great many mitogenic stimuli. PL C-{gamma}2 is an essential component of the signal transduction pathway between tyrosine kinases and downstream events such as protein kinase C activation and intracellular calcium release. The authors assigned PLCG2 to human chromosome 16 by amplification within a somatic cell hybrid mapping panel. To position the locus at a much finer resolution, PLCG2 sequences were amplified from a chromosome 16-specific somatic cell hybrid panel, which placed the gene on the long arm of the chromosome in band 16q24.1, a region that has few known genes. The authors have hybridized a mouse Plcg2 open reading frame probe to mouse DNAs from the European interspecific Backcross. The segregation pattern reveals the mouse Plcg2 locus maps to distal chromosome 8. 16 refs., 3 figs., 1 tab.
- OSTI ID:
- 255154
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 23; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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