Neutropenia fails to prevent the acute phase stimulation of fibrinogen synthesis
Journal Article
·
· Thromb. Res.; (United States)
This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (/sup 14/C) carbonate technique for the measurement of the absolute synthetic rates of liver produced plasma proteins it was observed that the rates of fibrinogen synthesis of the neutropenic and non-neutropenic rats were significantly greater (p less than 0.01) than those of normal control animals, but were not significantly different from each other. These results suggest that the neutrophil granulocyte may not be of major importance in mediating acute phase stimulation of fibrinogen synthesis.
- Research Organization:
- Department of Haematology, University of Cape Town Medical School, South Africa
- OSTI ID:
- 5999121
- Journal Information:
- Thromb. Res.; (United States), Journal Name: Thromb. Res.; (United States) Vol. 28:1; ISSN THBRA
- Country of Publication:
- United States
- Language:
- English
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· Proceedings of the National Academy of Sciences of the United States of America; (USA)
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
COAGULANTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FIBRINOGEN
FUNCTIONS
GLANDS
GLOBULINS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HEMOSTATICS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
LEUKOPENIA
LIVER
MAMMALS
MATERIALS
NEUTROPHILS
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
ORGANS
PATHOLOGY
PROTEINS
RATS
RODENTS
SOLVENTS
SYNTHESIS
TERPENES
TRACER TECHNIQUES
TURPENTINE
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
COAGULANTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FIBRINOGEN
FUNCTIONS
GLANDS
GLOBULINS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HEMOSTATICS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
LEUKOPENIA
LIVER
MAMMALS
MATERIALS
NEUTROPHILS
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
ORGANS
PATHOLOGY
PROTEINS
RATS
RODENTS
SOLVENTS
SYNTHESIS
TERPENES
TRACER TECHNIQUES
TURPENTINE
VERTEBRATES