In vitro cytotoxicity to alveolar macrophages of tar from a low-Btu coal gasifier
Journal Article
·
· Environ. Res.; (United States)
The cytotoxicity of fractions, subfractions, and some individual components present in tar from a low-Btu coal gasifier was determined in vitro with cultured dog alveolar macrophages. A subfraction of the tar which contained phenols and neutral nitrogen heterocycles was found to be a major contributor to the cytotoxic activity of the tar. Four compounds present in this subfraction were tested individually. Ranked from the most to the least toxic they were: 9-phenanthrol, 2-fluorenol, phenanthridone, and carbazole. 22 references, 4 figures, 1 table.
- Research Organization:
- Inhalation Toxicology Research Inst., Albuquerque, NM
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5997834
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 31; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
CHEMICAL ANALYSIS
COAL GASIFICATION
COAL TAR
CONNECTIVE TISSUE CELLS
DOGS
FLUIDS
FRACTIONATION
FUEL GAS
FUELS
GAS FUELS
GASES
GASIFICATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
LOW BTU GAS
MACROPHAGES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PHAGOCYTES
PHENOLS
SEPARATION PROCESSES
SOMATIC CELLS
TAR
THERMOCHEMICAL PROCESSES
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
CHEMICAL ANALYSIS
COAL GASIFICATION
COAL TAR
CONNECTIVE TISSUE CELLS
DOGS
FLUIDS
FRACTIONATION
FUEL GAS
FUELS
GAS FUELS
GASES
GASIFICATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
LOW BTU GAS
MACROPHAGES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PHAGOCYTES
PHENOLS
SEPARATION PROCESSES
SOMATIC CELLS
TAR
THERMOCHEMICAL PROCESSES
TOXICITY
VERTEBRATES