Direct heated interface probe for capillary supercritical fluid chromatography/double focusing mass spectrometry

Journal Article · Thu Dec 15 04:00:00 EST 1988 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00175a015· OSTI ID:5996216

Huang, E C; Jackson, B J; Markides, K E; Lee, M L

A capillary supercritical fluid chromatograph was occupied to a double focusing mass spectrometer with a direct heated probe interface. The interface contained a fused silica transfer capillary containing a frit restrictor at the end which was heated to a temperature of 300-350/degrees/C by resistance heating. The total column effluent was transferred into the mass spectrometer ion source. This interface not only preserved the chromatographic efficiency but also provided for mass spectral detection and identification of various high molecular weight, thermally labile, and polar compounds. Electron-impact and chemical ionization mass spectra of selected natural products and pharmaceuticals were obtained at the low nanogram level.

• Research Organization: Brigham Young Univ., Provo, UT (USA)
• DOE Contract Number: FG02-87ER60556
• OSTI ID: 5996216
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 60:24; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
400105* -- Separation Procedures
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHROMATOGRAPHY
DATA
DESIGN
DRUGS
EQUIPMENT INTERFACES
EXPERIMENTAL DATA
HEATING
INFORMATION
MASS SPECTROSCOPY
MINERALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
SEPARATION PROCESSES
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SPECTROSCOPY
SUPERCRITICAL FLUID CHROMATOGRAPHY
TRACE AMOUNTS