Effect of hydrogen fluoride inhalation on lipid metabolism in guinea pigs

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Artery (Fulton, Michigan); (United States)

OSTI ID:5996208

Philibert, C; Dousset, J C; Rioufol, C; Bourbon, P ^[1]

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1. Department of Toxicology, Faculte de Pharmacie, Toulouse (France)

The action of fluoride in vivo (exposure 96 hrs to 7 mg/m3) on the metabolism of cyclic AMP and relationship between cAMP and lipid metabolism was investigated. The mean values for cAMP, non esterified fatty acids and cholesterol were significantly increased after hydrogen fluoride exposure. cAMP is directly responsible for the increased lipolysis. In animals exposed to HF, theophylline injection causes increases of non esterified fatty acids and not produces modification of cholesterol level.

• OSTI ID: 5996208
• Journal Information: Artery (Fulton, Michigan); (United States), Vol. 18:5; ISSN 0098-6127
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYDROFLUORIC ACID
BIOLOGICAL EFFECTS
LIPIDS
METABOLISM
AMP
CHOLESTEROL
GUINEA PIGS
INHALATION
MAXIMUM PERMISSIBLE EXPOSURE
ANIMALS
FLUORINE COMPOUNDS
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INORGANIC ACIDS
INTAKE
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
RODENTS
SAFETY STANDARDS
STANDARDS
STEROIDS
STEROLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology