Mechanism of suppression of normal hemopoietic activity by lymphokine-activated killer cells and their products
Journal Article
·
· Experimental Hematology (Lawrence, Kansas); (United States)
OSTI ID:5996038
- Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London (England)
Interleukin 2 (IL-2)-activated lymphocytes (lymphokine-activated killer (LAK) cells) have been shown to inhibit the formation of autologous human granulocyte-macrophage hemopoietic progenitors (granulocyte-macrophage colony-forming units, CFU-GM) in vitro. Effects of LAK cells on these progenitors may include a number of different mechanisms. LAK cells are potent cytotoxic lymphocytes capable of lysing certain normal autologous cells. They also produce cytokines known to inhibit hemopoiesis (interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha)) or enhance it (granulocyte-macrophage colony-stimulating factor, GM-CSF). In the authors' current study they analyzed the mechanism of suppression of autologous CFU-GM by LAK cells. Their results suggest that LAK cells are not directly cytotoxic to normal CFU-GM. They show that it is possible to abolish the hemopoiesis-inhibiting activity of LAK cells without abrogating their cytotoxicity against tumor cell lines using inhibitors of DNA synthesis, namely hydroxyurea or irradiation.
- OSTI ID:
- 5996038
- Journal Information:
- Experimental Hematology (Lawrence, Kansas); (United States), Journal Name: Experimental Hematology (Lawrence, Kansas); (United States) Vol. 19:7; ISSN EXHMA; ISSN 0301-472X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DNA REPLICATION
ENZYME INHIBITORS
GROWTH FACTORS
HYDROXY COMPOUNDS
HYDROXYUREA
IMMUNOSUPPRESSION
INTERFERON
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MACROPHAGES
MATERIALS
MITOGENS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PROTEINS
SOMATIC CELLS
STEM CELLS
Cells
& Tissue Culture
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DNA REPLICATION
ENZYME INHIBITORS
GROWTH FACTORS
HYDROXY COMPOUNDS
HYDROXYUREA
IMMUNOSUPPRESSION
INTERFERON
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MACROPHAGES
MATERIALS
MITOGENS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PROTEINS
SOMATIC CELLS
STEM CELLS