Systemic effects of low-power laser irradiation on the peripheral and central nervous system, cutaneous wounds, and burns

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Lasers Surg. Med.; (United States)

DOI:https://doi.org/10.1002/lsm.1900090214· OSTI ID:5994481

Rochkind, S; Rousso, M; Nissan, M; Villarreal, M; Barr-Nea, L; Rees, D G

In this paper, we direct attention to the systemic effect of low-power helium-neon (HeNe) laser irradiation on the recovery of the injured peripheral and central nervous system, as well as healing of cutaneous wounds and burns. Laser irradiation on only the right side in bilaterally inflicted cutaneous wounds enhanced recovery in both sides compared to the nonirradiated control group (P less than .01). Similar results were obtained in bilateral burns: irradiating one of the burned sites also caused accelerated healing in the nonirradiated site (P less than .01). However, in the nonirradiated control group, all rats suffered advanced necrosis of the feet and bilateral gangrene. Low-power HeNe laser irradiation applied to a crushed injured sciatic nerve in the right leg in a bilaterally inflicted crush injury, significantly increased the compound action potential in the left nonirradiated leg as well. The statistical analysis shows a highly significant difference between the laser-treated group and the control nonirradiated group (P less than .001). Finally, the systemic effect was found in the spinal cord segments corresponding to the crushed sciatic nerves. The bilateral retrograde degeneration of the motor neurons of the spinal cord expected after the bilateral crush injury of the peripheral nerves was greatly reduced in the laser treated group. The systemic effects reported here are relevant in terms of the clinical application of low-power laser irradiation as well as for basic research into the possible mechanisms involved.

• Research Organization: Tel Aviv Medical Center, Ichilov Hospital (Israel)
• OSTI ID: 5994481
• Journal Information: Lasers Surg. Med.; (United States), Journal Name: Lasers Surg. Med.; (United States) Vol. 9:2; ISSN LSMED
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
BURNS
CENTRAL NERVOUS SYSTEM
ELECTROMAGNETIC RADIATION
GAS LASERS
HEALING
HELIUM-NEON LASERS
INJURIES
LASER RADIATION
LASERS
MAMMALS
NERVES
NERVOUS SYSTEM
ORGANS
RADIATIONS
RATS
RECOVERY
RODENTS
SKIN
SPINAL CORD
VERTEBRATES
WOUNDS