Effects of dopamine in the renal vascular bed of fetal, newborn, and adult sheep

Journal Article · Sun Mar 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5993906

Nakamura, K T; Felder, R A; Jose, P A; Robillard, J E

The renal hemodynamic response to renal arterial dopamine infusions was compared in unanesthetized fetal, newborn, and adult sheep. Mean arterial blood pressure and heart rate remained unchanged during intrarenal dopamine infusions. Dopamine produced dose-related decreases in mean renal blood flow velocity in all three groups. When compared with adult sheep fetal sheep were slightly more sensitive to the vasoconstrictive effects of dopamine ED/sub 50/. Increases in mean renal blood flow velocity were not seen at any dose given until dopamine was infused during ..cap alpha..- and ..beta..-adrenoceptor blockade. The largest mean increase in renal flow velocity was 13 +/- 3, 16 +/- 3, and 17 +/- 4% in fetal, newborn, and adult sheep, respectively. cis-Flupentixol inhibited the vasodilation. Renal blood flow was measured using the radioactive microspheres techniques. This study demonstrates the presence of renal vasodilation following renal arterial dopamine infusions in fetal, newborn, and adult sheep when renal ..cap alpha..- and ..beta..-adrenoceptors are blocked. Vasodilator responses are similar in all three groups, and increases in renal blood flow velocity are small compared with that of other experimental models.

• Research Organization: Univ. of Iowa, Iowa City
• OSTI ID: 5993906
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:3; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
AGE GROUPS
ALKALINE EARTH ISOTOPES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
DOPAMINE
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FETUSES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
MEMBRANE PROTEINS
MICROSPHERES
NEONATES
NEUROREGULATORS
NIOBIUM 95
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PHYSIOLOGY
POLYPHENOLS
PROTEINS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RECEPTORS
RUMINANTS
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
SHEEP
STRONTIUM 85
STRONTIUM ISOTOPES
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES