Peroxidation of the dried thin film of lipid by high-energy alpha particles from a cyclotron
High-energy ..cap alpha.. particles produced a dose-dependent linear increase in different lipid peroxidation products (e.g., malondialdehyde (MDA), conjugated dienes, and hydroperoxides) in the dried thin film state. An inverse dose-rate effect was observed when the dose rate was varied by changing either the ..cap alpha..-particle fluence rate or the ..cap alpha..-particle energy. The antioxidants ..cap alpha..-tocopherol and butylated hydroxytoluene (BHT) suppressed the ..cap alpha..-particle-induced lipid peroxidation in the dried thin film state, and in this respect ..cap alpha..-tocopherol was found superior to BHT. It was found that ..cap alpha..-tocopherol was equally efficient in inhibiting lipid peroxidations by ..cap alpha.. particles and ultraviolet light.
- Research Organization:
- Saha Inst. of Nuclear Physics, Calcutta, India
- OSTI ID:
- 5993661
- Journal Information:
- Radiat. Res.; (United States), Vol. 100:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIPIDS
CHEMICAL RADIATION EFFECTS
ALPHA PARTICLES
ANTIOXIDANTS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
EXTREME ULTRAVIOLET RADIATION
LECITHINS
PEROXIDES
VARIABLE ENERGY CYCLOTRONS
ACCELERATORS
CHARGED PARTICLES
CHEMISTRY
CYCLIC ACCELERATORS
CYCLOTRONS
DATA
ELECTROMAGNETIC RADIATION
ESTERS
INFORMATION
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHOLIPIDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
ULTRAVIOLET RADIATION
400600* - Radiation Chemistry