Considerations in the interpretation of animal bioassays for chemical carcinogenicity

Conference · Sat Jan 01 04:00:00 EST 1983

OSTI ID:5991085

Griesemer, R A

Animal bioassays are the single most important source of information about the capacity of chemical substances to produce cancer. In contrast with mutagenesis assays, animal bioassays can be considered definitive for detecting carcinogens because the end point is the production of cancer. In contrast with studies in humans, animal bioassays are experimentally controlled so that cause and effect relationships can be more clearly established. The primary importance of animal bioassays for carcinogenicity is the identification of carcinogens so that measures can be taken to prevent cancer in humans. They are also important in providing a base of data about carcinogenicity for the validation of short-term tests. Since the validation of other tests depends on the accuracy with which animal bioassays detect carcinogens, it is surprising that animal bioassay experiments have not been subjected to more critical evaluation. The purpose of this report is to increase awareness of some of the factors that should be considered in utilizing animal bioassay data.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5991085
• Report Number(s): CONF-830480-1; ON: DE83012349
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
CARCINOGEN SCREENING
EVALUATION
EXPERIMENT PLANNING
LABORATORY ANIMALS
PLANNING
SCREENING
TESTING
VALIDATION