Overview of bioassays for mutagens, carcinogens, and teratogens
Conference
·
OSTI ID:5171834
Bioassays to determine the risk of health hazards of man-made chemical substances are reviewed. The standard approach to testing a substance is the tier system, consisting of three levels of testing that are increasingly complex, lengthy, and costly. The paper describes the biological basis of bioassays, identifies various assays for mutagens, carcinogens and teratogens, and explains the problems involved in extrapolating test data to human risk estimates. Future improvements in assay techniques are discussed. (CR)
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5171834
- Report Number(s):
- CONF-820418-19; ON: DE82017435
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mutagenicity, carcinogenicity, and teratogenicity of industrial pollutants
In vitro testing for carcinogens and mutagens
Cell-specific activation of chemical carcinogens into mutagens for cultured human and rodent cells
Book
·
Sat Dec 31 23:00:00 EST 1983
·
OSTI ID:6497612
In vitro testing for carcinogens and mutagens
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· State Art Rev. Occup. Med.; (United States)
·
OSTI ID:6064888
Cell-specific activation of chemical carcinogens into mutagens for cultured human and rodent cells
Conference
·
Mon Dec 31 23:00:00 EST 1984
·
OSTI ID:5564734
Related Subjects
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
CARCINOGEN SCREENING
DOCUMENT TYPES
FORECASTING
MUTAGEN SCREENING
REVIEWS
SCREENING
TERATOGEN SCREENING
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
CARCINOGEN SCREENING
DOCUMENT TYPES
FORECASTING
MUTAGEN SCREENING
REVIEWS
SCREENING
TERATOGEN SCREENING