Effect of histamine and H/sub 1/- and H/sub 2/-agonists on the fractional outflow of radioactivity from the rat vas deferens and preloaded with (/sup 3/H)-noradrenaline
Histamine and relatively selective H/sub 1/- and H/sub 2/-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H/sub 1/- or H/sub 2/-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca/sup 2 +/ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.
- OSTI ID:
- 5983735
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Journal Issue: 25 Vol. 31:25; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALINE EARTH METAL COMPOUNDS
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CALCIUM COMPOUNDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATIONS
CHARGED PARTICLES
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HORMONES
IMIDAZOLES
IONS
LABELLED COMPOUNDS
MALE GENITALS
MAMMALS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RECEPTORS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VERTEBRATES