Bradykinin modulates the release of noradrenaline from vas deferens nerve terminals

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90616-J· OSTI ID:5272301

Llona, I; Galleguillos, X; Belmar, J; Huidobro-Toro, J P ^[1]

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1. Catholic Univ. of Chile, Santiago (Chile)

To asses whether bradykinin influences the release of noradrenaline from the adrenergic varicosities of the vas deferens, tissues were loaded with {sup 3}H-noradrenaline. Upon electrical depolarization bradykinin increased in a concentration-dependent fashion, the overflow of tritium from the mouse or rat vas deferens. The {sup 3}H-overflow is dependent on the external Ca2+concentration suggesting neuronal release of {sup 3}H-noradrenaline. The present results add evidence to the hypothesis that bradykinin modulates the release of noradrenaline from peripheral sympathetic nerve terminals via the activation of a presynpatic mechanism.

• OSTI ID: 5272301
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 48:26; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GONADS
HORMONES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
KININS
MALE GENITALS
MAMMALS
MICE
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RATS
REACTION KINETICS
RODENTS
SECRETION
SYMPATHOMIMETICS
TESTES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES