Altered regional myocardial metabolism in congestive cardiomyopathy detected by positron tomography

Journal Article · Sun May 01 00:00:00 EDT 1983 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(83)91065-3· OSTI ID:5980107

Geltman, E M; Smith, J L; Beecher, D; Ludbrook, P A; Ter-Pogossian, M M; Sobel, B E

The present study was performed to determine whether positron emission tomography performed after intravenous injection of /sup 11/C-palmitate permits detection and characterization of congestive cardiomyopathy. Positron emission tomography was performed after the intravenous injection of /sup 11/C-palmitate in 13 normal subjects, 17 patients with congestive cardiomyopathy, and six patients with initial transmural myocardial infarction (defined electrocardiographically). Regionally depressed accumulation of /sup 11/C-palmitate was assessed, characterized, and quantified in seven parallel transaxial reconstructions in each patient. Patients with cardiomyopathy exhibited a larger number of discrete noncontiguous regions of accumulation of palmitate within the myocardium than either control subjects or patients with transmural infarction (17.4 +/- 0.6 (SEM) versus 11.8 +/- 0.7 versus 10.3 +/- 0.6, p less than 0.005). Similarly, regions of accumulation of palmitate were irregularly shaped in patients with cardiomyopathy, with a longer normalized perimeter than either control subjects or patients with transmural infarction (2.0 +/- 0.05 versus 1.8 +/- 0.06 versus 1.9 +/- 0.09, p less than 0.05). Regional abnormalities of the accumulation of 11C-palmitate could not be explained by regional differences in left ventricular wall motion or myocardial perfusion. Thus, marked heterogeneity of regional myocardial accumulation of 11C-palmitate is detectable and quantifiable in patients with congestive cardiomyopathy by positron emission tomography and may be particularly valuable for early detection and characterization of cardiomyopathy.

• Research Organization: Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
• OSTI ID: 5980107
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 74:5; ISSN AJMEA
• Country of Publication: United States
• Language: English

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