Granulocyte antigen systems and antibodies and their clinical significance

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Hum. Pathol.; (United States)

DOI:https://doi.org/10.1016/S0046-8177(83)80022-7· OSTI ID:5979681

McCullough, J

Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.

• Research Organization: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis
• OSTI ID: 5979681
• Journal Information: Hum. Pathol.; (United States), Vol. 14:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LEUKOCYTES
ANTIBODIES
TRANSFUSIONS
ANTIGENS
GRAFT-HOST REACTION
IMMUNITY
INDIUM 111
LABELLED COMPOUNDS
LEUKOPENIA
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEMIC DISEASES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
THERAPY
550601* - Medicine- Unsealed Radionuclides in Diagnostics