Granulocyte-associated IgG in neutropenic disorders

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Blood; (United States)

OSTI ID:5368132

Cines, D B; Passero, F; Guerry, D; Bina, M; Dusak, B; Schreiber, A D

We applied a radiolabeled antiglobulin test to a study of patients with a variety of neutropenic disorders. After defining the nature of the interaction of radiolabeled anti-IgG with the neutrophil, we studied 16 patients with neutropenia of uncertain etiology and adequate bone marrow granulocyte precursors. Twelve of these 16 patients had increased neutrophil-associated IgG (PMN-IgG). Patients with the highest levels of PMN-IgG had the lowest neutrophil counts. The majority of patients with neutropenia and increased PMN-IgG had an underlying immunologic disorder that included immune thrombocytopenic purpura in 5 patients and autoimmune hemolytic anemia in 1 patient. In some patients, elevated PMN-IgG preceded other evidence for immunologic disease. The direct antiglobulin test helped to distinguish neutropenic patients with increased PMN-IgG both from patients with neutropenia due to a known nonimmune disorder and from nonneutropenic patients with rheumatoid arthritis or systemic lupus erythematosis. Each of four patients with increased neutrophil-associated IgG treated with systemic corticosteroids responded clinically with an associated fall in neutrophil IgG and a rise in the circulating neutrophil count. The radiolabeled antiglobulin test appears useful in defining a subpopulation of patients with neutropenia due to an underlying immunologic disorder.

• Research Organization: Hematology-Oncology Section, University of Pennsylvania School of Medicine, Philadelphia
• OSTI ID: 5368132
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 59:1; ISSN BLOOA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DIAGNOSIS
DISEASES
ETIOLOGY
GLOBULINS
HEMIC DISEASES
IMMUNOGLOBULINS
IMMUNOLOGY
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LEUKOPENIA
MATERIALS
NEUTROPHILS
ORGANIC COMPOUNDS
PATHOLOGY
PATIENTS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
TRACER TECHNIQUES