Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets
Journal Article
·
· New Engl. J. Med.; (United States)
We applied a radiolabeled Coombs antiglobulin test to the diagnosis and management of immune thrombocytopenia in adults and children. This assay substantiated that the majority of patients with idiopathic thrombocytopenic purpura have increased levels of IgG on their platelets. Platelets from a patient with the post-transfusion-purpura syndrome also carried increased IgG, indicating a role for IgG antibody or IgG-containing immune complexes in the destruction of host platelets in this disease. The radiolabeled Coombs test provides a general means to help diagnose, manage, and study immune platelet disorders.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 6739032
- Journal Information:
- New Engl. J. Med.; (United States), Journal Name: New Engl. J. Med.; (United States) Vol. 300:3; ISSN NEJMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CORTICOSTEROIDS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
GLOBULINS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IMMUNOGLOBULINS
IODINE ISOTOPES
ISOTOPES
KETONES
MATERIALS
ORGANIC COMPOUNDS
PATIENTS
PREGNANES
PROTEINS
PURPURA
STEROID HORMONES
STEROIDS
USES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CORTICOSTEROIDS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
GLOBULINS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IMMUNOGLOBULINS
IODINE ISOTOPES
ISOTOPES
KETONES
MATERIALS
ORGANIC COMPOUNDS
PATIENTS
PREGNANES
PROTEINS
PURPURA
STEROID HORMONES
STEROIDS
USES