Granulocyte antigen systems and antibodies and their clinical significance

Journal Article · Tue Mar 01 04:00:00 EST 1983 · Hum. Pathol.; (United States)

DOI:https://doi.org/10.1016/S0046-8177(83)80022-7· OSTI ID:5979681

McCullough, J

Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.

• Research Organization: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis
• OSTI ID: 5979681
• Journal Information: Hum. Pathol.; (United States), Journal Name: Hum. Pathol.; (United States) Vol. 14:3; ISSN HPCQA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GRAFT-HOST REACTION
HEMIC DISEASES
IMMUNITY
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LEUKOPENIA
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS