Modified biokinetic model for uranium from analysis of acute exposure to UF6

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-199103000-00002· OSTI ID:5979384

Fisher, D R; Kathren, R L; Swint, M J ^[1]

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1. Pacific Northwest Laboratory, Richland, WA (USA)

Urinalysis measurements from 31 workers acutely exposed to uranium hexafluoride (UF6) and its hydrolysis product UO2F2 (during the 1986 Gore, Oklahoma UF6-release accident) were used to develop a modified recycling biokinetic model for soluble U compounds. The model is expressed as a five-compartment exponential equation: yu(t) = 0.086e-2.77t + 0.0048e-0.116t + 0.00069e-0.0267t + 0.00017 e-0.00231t + 2.5 x 10(-6) e-0.000187t, where yu(t) is the fractional daily urinary excretion and t is the time after intake, in days. The excretion constants of the five exponential compartments correspond to residence half-times of 0.25, 6, 26, 300, and 3,700 d in the lungs, kidneys, other soft tissues, and in two bone volume compartments, respectively. The modified recycling model was used to estimate intake amounts, the resulting committed effective dose equivalent, maximum kidney concentrations, and dose equivalent to bone surfaces, kidneys, and lungs.

• OSTI ID: 5979384
• Journal Information: Health Physics; (USA), Journal Name: Health Physics; (USA) Vol. 60:3; ISSN 0017-9078; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCIDENTS
ACTINIDE COMPOUNDS
ACUTE EXPOSURE
BIOLOGICAL HALF-LIFE
BODY BURDEN
DISTRIBUTION
FLUORIDES
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
MATHEMATICAL MODELS
METABOLISM
OCCUPATIONAL EXPOSURE
RADIATION ACCIDENTS
TISSUE DISTRIBUTION
URANIUM COMPOUNDS
URANIUM FLUORIDES
URANIUM HEXAFLUORIDE