Preparation and surface characterization of PEO-grafted and heparin-immobilized polyurethanes

Journal Article · Sat Apr 01 04:00:00 EST 1989 · J. Biomed. Mater. Res.; (United States)

DOI:https://doi.org/10.1002/jbm.820231309· OSTI ID:5977895

Han, D K; Park, K D; Ahn, K D; Jeong, S Y; Kim, Y H

Surfaces of commercial polyurethanes (PUs) were modified by poly(ethylene oxide) (PEO) grafting and/or heparin immobilization for long-term biomedical applications. PU surfaces were treated with diisocyanate and then reacted with PEO or heparin. The heparin immobilized by various methods on the PU surface was very stable, with concentrations of 1.45-1.84 micrograms/cm/sup 2/. Surface structure and characteristics of each modified PU were examined by performing the following surface analyses: attenuated total reflection infrared (ATR-IR), electron spectroscopy for chemical analysis (ESCA), scanning electron microscopy (SEM), and dynamic contact angle measurements. The reaction scheme and surface chemical structure of modified PUs were confirmed by ATR-IR and ESCA, respectively. SEM results showed that the PU-PEO surface was very smooth and that the smoothness of the heparinized PU surfaces varied, depending upon the solvent and coupling agent used in the process. The hydrophilicity of the surface was significantly increased after PEO grafting or heparin immobilization. Increase in the chain length of the grafted PEO resulted in significant increases in hydrophilicity and surface mobility.

• Research Organization: Korea Advanced Institute of Science and Technology, Cheongryang, Seoul
• OSTI ID: 5977895
• Journal Information: J. Biomed. Mater. Res.; (United States), Journal Name: J. Biomed. Mater. Res.; (United States) Vol. 23; ISSN JBMRB
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
360603* -- Materials-- Properties
550600 -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
AMINES
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOHYDRATES
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
DRUGS
ELECTRON MICROSCOPY
GLYCOLS
HEMATOLOGIC AGENTS
HEPARIN
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
MATERIALS
MICROSCOPY
MUCOPOLYSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYETHYLENE GLYCOLS
POLYMERS
POLYSACCHARIDES
POLYURETHANES
SACCHARIDES
SCANNING ELECTRON MICROSCOPY
SURFACE PROPERTIES
SYNTHESIS
SYNTHETIC MATERIALS
THERMODYNAMICS
WATER